People who eat fewer calories for many years have less inflammation in their muscles compared to people who don't restrict calories, which may help keep muscles healthier.

Scientific Claim

Long-term calorie restriction in humans is associated with reduced inflammation in skeletal muscle compared to control groups, suggesting improved cellular environment.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and only shows association, so 'associated with' is appropriate. The claim correctly states the finding without implying causation.

Source Excerpt

“Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The abstract states 'reduced inflammation' in the CR group compared to controls, though specific measurements aren't detailed. This is a direct observation without causal inference.

Score

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Cross-Sectional Study

Supported

Source Study

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Score: 37

DOI: 10.1016/j.celrep.2015.12.042

Similar Assertions

People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which may help keep cells healthier.

74%

People who eat fewer calories for many years have more of a protein called HSP70 in their muscles, which helps cells handle stress better.

72%

People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which might explain why calorie restriction could slow aging.

71%

People who eat fewer calories for many years have more of a protein called Grp78 in their muscles, which helps cells deal with stress in the part of the cell that makes proteins.

71%