People who eat fewer calories for many years have more of a protein called HSP70 in their muscles, which helps cells handle stress better.

Scientific Claim

Long-term calorie restriction in humans is associated with higher levels of HSP70 protein and mRNA in skeletal muscle compared to control groups, indicating enhanced cellular stress response mechanisms.

Original Statement

“HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls.”

From study:Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and only shows association, so 'associated with' is appropriate. The claim correctly states the finding without implying causation.

Evidence from Studies

Supporting (1)

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Score: 37

DOI: 10.1016/j.celrep.2015.12.042

Similar Assertions

People who eat fewer calories for many years have more of a protein called Grp78 in their muscles, which helps cells deal with stress in the part of the cell that makes proteins.

82%

People who eat fewer calories for many years have more proteins in their muscles that help clean up damaged proteins and cell parts, which may help keep cells healthier.

74%

People who eat fewer calories for many years have less inflammation in their muscles compared to people who don't restrict calories, which may help keep muscles healthier.

72%