People who eat fewer calories for many years have more of a protein called Grp78 in their muscles, which helps cells deal with stress in the part of the cell that makes proteins.

Scientific Claim

Long-term calorie restriction in humans is associated with higher levels of Grp78 protein and mRNA in skeletal muscle compared to control groups, suggesting enhanced endoplasmic reticulum stress response.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and only shows association, so 'associated with' is appropriate. The claim correctly states the finding without implying causation.

Source Excerpt

“HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls.”

Evidence from Studies

Supporting Evidence (1)

Why it supports

The study measured Grp78 levels in skeletal muscle and found higher levels in CR subjects versus controls. This is a direct observation without causal inference.

Score

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Cross-Sectional Study

Supported

Source Study

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Score: 37

DOI: 10.1016/j.celrep.2015.12.042

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