If you're a healthy young adult getting back into strength training after resting your leg for two weeks, taking creatine might give you more energy in your muscles and boost creatine levels after three weeks — but by ten weeks, that advantage goes away.

Taking creatine while rebuilding leg strength after being inactive might help your muscles improve faster by boosting a key protein that helps with energy use.

Taking creatine every day while your leg is immobilized might help keep your muscles' ability to handle sugar working better, so they don’t weaken as much.

Taking creatine for five days boosts creatine in muscles, but doesn’t change how much glycogen (energy) is used during intense cycling in healthy young guys — so more creatine alone doesn’t help save energy stores during endurance workouts if muscles weren’t already drained.

Taking creatine supplements the way some athletes do—starting with a big dose, then switching to a smaller one—might temporarily boost the sugar stored in your muscles, but that boost fades once you switch to the smaller daily dose.

If young, healthy guys take 20 grams of creatine every day while eating a super high-carb diet after intense exercise, they rebuild their muscle fuel 82% faster in the first day compared to just eating high carbs alone.