People with a certain gene variation who eat a lot of broccoli for two weeks see lower levels of two inflammation markers in their blood.

Scientific Claim

In healthy young adults aged 20–40 with the GSTM1-null/GSTT1+ genotype, consumption of 14 g/kg body weight of cruciferous vegetables per day for 14 days reduces serum interleukin-8 (IL-8) by 33% and soluble TNF receptor I (sTNFRI) by 7.5%, indicating a genotype-specific anti-inflammatory effect on these biomarkers.

Original Statement

“There were significant differences between GSTM1-null/GSTT1+ individuals [...] with the 2xC diet compared with the basal diet (IL-8: -33.2%; 95% CI: -43.0%, -1.4%; sTNFRI: -7.5%; 95% CI: -12.7%, -2.3%).”

From study:Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The RCT design with pre-specified genotype subgroups and statistical significance allows definitive causal claims within the defined genetic subgroup.

Evidence from Studies

Supporting (1)

Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Randomized Controlled Trial

Human

This study found that for people with a specific gene type, eating a lot of broccoli and similar veggies for two weeks lowered two key inflammation markers in their blood—exactly as the claim says.

Contradicting (0)

No contradicting evidence found

Source Study

Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Score: 69

DOI: 10.3945/jn.114.197434

Similar Assertions

Eating a mix of broccoli and carrots every day for two weeks slightly increases another inflammation marker in the blood of healthy young people.

91%

For people with a certain gene combination, eating broccoli for two weeks actually made one inflammation marker go up instead of down.

89%

People with a specific genetic variation who eat a mix of broccoli and carrots for two weeks see big drops in two key inflammation markers in their blood.

89%

People with a certain gene variation who eat a lot of broccoli for two weeks see a small but measurable drop in proteins that control inflammation signals in their blood.

87%

Eating a moderate amount of broccoli for two weeks might lower inflammation in some people with a certain gene, but the effect isn't strong enough to be sure yet.

86%