People with a specific genetic variation who eat a mix of broccoli and carrots for two weeks see big drops in two key inflammation markers in their blood.

Scientific Claim

In healthy young adults aged 20–40 with the GSTM1-null/GSTT1+ genotype, consumption of 7 g/kg body weight of cruciferous vegetables plus 4 g/kg body weight of apiaceous vegetables per day for 14 days reduces serum C-reactive protein (CRP) by 38% and interleukin-6 (IL-6) by 49%, demonstrating a genotype-dependent anti-inflammatory response.

Original Statement

“There were significant differences between GSTM1-null/GSTT1+ individuals for several biomarkers in response to 1xC+A compared with basal diets (CRP: -37.8%; 95% CI: -58.0%, -7.4%; IL-6: -48.6%; 95% CI: -49.6%, -12.0%).”

From study:Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The RCT included pre-specified genotype stratification and found statistically significant effects only in this subgroup. The causal language is justified within the defined population.

Evidence from Studies

Supporting (1)

Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Randomized Controlled Trial

Human

The study found that for people with a specific gene type, eating lots of broccoli and carrots for two weeks lowered two key inflammation markers almost exactly as the claim said—so the claim is backed up by solid evidence.

Contradicting (0)

No contradicting evidence found

Source Study

Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults.

Score: 69

DOI: 10.3945/jn.114.197434

Similar Assertions

For people with a certain gene combination, eating broccoli for two weeks actually made one inflammation marker go up instead of down.

92%

Eating a moderate amount of broccoli for two weeks might lower inflammation in some people with a certain gene, but the effect isn't strong enough to be sure yet.

90%

People with a certain gene variation who eat a lot of broccoli for two weeks see lower levels of two inflammation markers in their blood.

89%

Eating a lot of broccoli, cabbage, and similar veggies every day for two weeks can lower a key inflammation marker in the blood of healthy young people.

88%

Eating a mix of broccoli and carrots every day for two weeks lowers a blood inflammation marker just as much as eating a lot of broccoli alone.

86%