People with a genetic condition that gives them high cholesterol are much more likely to have a heart attack or stroke within 10 years if they also have metabolic syndrome — even if their cholesterol...

People with this inherited high-cholesterol condition who also have metabolic syndrome are almost five times more likely to die from any cause over the next 30 years.

If someone has high cholesterol from birth and also has metabolic syndrome, they’re nearly five times more likely to have a heart attack, stroke, or need a heart procedure within 10 years.

If young adults with a genetic form of high cholesterol have been exposed to high LDL levels for longer, they tend to have twice as much plaque buildup in their arteries for every 75 units of exposure over time — meaning long-term cholesterol exposure might silently damage their heart vessels.

Young adults with a genetic cholesterol problem are more likely to have heart artery plaque than their peers without it — more than half of them do, compared to about one in five others.

High LDL cholesterol might not always lead to heart disease if a person is metabolically healthy — it could depend on whether they have insulin resistance or other metabolic issues.