People with this inherited high-cholesterol condition who also have metabolic syndrome are almost five times more likely to die from any cause over the next 30 years.

52

Pro

0

Against

Evidence from Studies

Supporting (1)

52

Community contributions welcome

52

Metabolic syndrome predicts cardiovascular risk and mortality in familial hypercholesterolemia.

Cohort Study

Human

2023 May-Jun

This study found that adults with a genetic cholesterol disorder who also have metabolic syndrome (like being overweight, having high blood pressure or sugar) are nearly five times more likely to die over 30 years than those without metabolic syndrome — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Metabolic syndrome predicts cardiovascular risk and mortality in familial hypercholesterolemia.

Score: 52

DOI: 10.1016/j.jacl.2023.03.008

Similar Assertions

People with a genetic condition that gives them high cholesterol are much more likely to have a heart attack or stroke within 10 years if they also have metabolic syndrome — even if their cholesterol is being managed.

52

0

94%

If someone has high cholesterol from birth and also has metabolic syndrome, they’re nearly five times more likely to have a heart attack, stroke, or need a heart procedure within 10 years.

52

0

90%

Adult males with metabolic syndrome based on National Cholesterol Education Program guidelines have a 73% higher chance of silent heart disease compared to those without, according to the study. This finding is from the abstract summary - full study details were not available

48

0

73%