Why having extra body fat and high blood pressure is extra dangerous for people with high cholesterol
Metabolic syndrome predicts cardiovascular risk and mortality in familial hypercholesterolemia.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People born with a genetic condition that gives them very high cholesterol (FH) are already at risk for heart problems. But if they also have metabolic syndrome—like being overweight, having high blood pressure, or high blood sugar—they’re even more likely to have heart attacks or die early.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 552 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People born with a genetic condition that gives them very high cholesterol (FH) are already at risk for heart problems. But if they also have metabolic syndrome—like being overweight, having high blood pressure, or high blood sugar—they’re even more likely to have heart attacks or die early.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 552 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Paquette M, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A
Related Content
Claims (4)
If someone has high cholesterol from birth and also has metabolic syndrome, they’re nearly five times more likely to have a heart attack, stroke, or need a heart procedure within 10 years.
People with this inherited high-cholesterol condition who also have metabolic syndrome are almost five times more likely to die from any cause over the next 30 years.
Cardiovascular risk persists despite low LDL cholesterol levels if concomitant metabolic syndrome, hypertension, chronic inflammation, or dysglycemia remain unaddressed.
People with a genetic condition that gives them high cholesterol are much more likely to have a heart attack or stroke within 10 years if they also have metabolic syndrome — even if their cholesterol is being managed.