For people with fatty liver disease, taking a supplement called GLS for 12 weeks along with healthy lifestyle changes seems to lower a stress-related liver hormone (FGF-21) more than another supplement. This might mean their liver isn’t working as hard to stay healthy after treatment.

If you have fatty liver and take a supplement called GLS for 12 weeks, the more your FGF-21 levels go down, the more your liver enzyme and belly size tend to improve — suggesting this protein might be a marker for better liver and metabolic health.

If you're an adult with fatty liver disease, taking a supplement called GLS for 12 weeks along with healthy lifestyle changes might help you lose more belly fat and weight than another supplement, with an average of nearly 3.5 pounds more lost.

If you're an adult with fatty liver disease, taking a supplement called GLS for 12 weeks—along with healthy lifestyle changes—might lower your bad cholesterol and fats in the blood more than another treatment, which could be better for your heart health.

When mice don't have enough of a protein called FGF21 during fasting, their livers store more fat because they burn less fat and take in more from the blood — but this doesn't affect how the body overall uses energy.

People with obesity, prediabetes, or type 2 diabetes tend to have higher levels of a hormone called FGF-21 in their blood compared to healthy-weight people, and the more severe the metabolic issue, the higher the level seems to go.