People who have multiple autoantibodies related to type 1 diabetes but still have normal blood sugar levels show lower levels of the hormone GIP after consuming glucose, compared to those with only...

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18-OR: Lower Incretin Effect and Reduced GIP Characterize the Metabolic Phenotype of People with Multiple Islet Autoantibodies and Normal Glucose Tolerance

Cross-Sectional Study

Human

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Source Study

18-OR: Lower Incretin Effect and Reduced GIP Characterize the Metabolic Phenotype of People with Multiple Islet Autoantibodies and Normal Glucose Tolerance

Score: 48

DOI: 10.2337/db25-18-or

Similar Assertions

People who have multiple autoantibodies targeting their pancreatic islets but still have normal blood sugar levels show a 45% decrease in the hormone response that helps regulate insulin after eating, along with lower levels of the GIP hormone during a glucose test, indicating early metabolic changes before diabetes develops.

83%

People who have multiple antibodies targeting their insulin-producing cells but still have normal blood sugar tend to show lower levels of GLP-1 hormone during a glucose tolerance test than those with only one such antibody, though the difference is not large enough to be considered statistically reliable in this small group.

81%

In people who have antibodies indicating early risk for type 1 diabetes but still have normal blood sugar, a decrease in the hormone GIP—compared to GLP-1—appears to be the main reason for reduced insulin response after eating, which may make GIP a better early indicator of pancreatic beta-cell stress.

78%