People with obesity and knee arthritis who took a weekly semaglutide shot for over a year felt physically better than those who took a dummy shot — their ability to do everyday physical activities improved more, by about twice as much.

A weekly shot called semaglutide helped people with obesity and bad knee arthritis lose way more weight—about 13.7% of their body weight—compared to a fake shot that only led to 3.2% loss, and that weight loss might help their joint pain feel better.

A weekly semaglutide shot helped people with obesity and knee pain from arthritis feel a lot better—much more than those who got a dummy shot.

People with obesity and another health issue who got a weekly shot of semaglutide plus behavioral therapy lost about 17 kg on average after a year and a half — way more than those who got a placebo.

Taking a weekly semaglutide shot (2.4 mg) for about a year helps people with extra weight feel more physically capable and improves their overall quality of life—more than a dummy pill would.

For adults who aren't diabetic but carry extra weight, a weekly injection of semaglutide (2.4 mg) plus healthy lifestyle changes led to nearly 15% weight loss over a year and a half—way more than lifestyle changes alone.