A shot that helps people with heavy knees feel better
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people who weigh a lot and have bad knee pain got a weekly shot for over a year. One group got a medicine called semaglutide, and the other got a fake shot. Everyone also got advice on moving more and eating less.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 567 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people who weigh a lot and have bad knee pain got a weekly shot for over a year. One group got a medicine called semaglutide, and the other got a fake shot. Everyone also got advice on moving more and eating less.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 567 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Bliddal H, Bays H, Czernichow S, Uddén Hemmingsson J, Hjelmesæth J, Hoffmann Morville T, Koroleva A, Skov Neergaard J, Vélez Sánchez P, Wharton S, Wizert A, Kristensen LE, STEP 9 Study Group
Related Content
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Claims (3)
A weekly semaglutide shot helped people with obesity and knee pain from arthritis feel a lot better—much more than those who got a dummy shot.
People with obesity and knee arthritis who took a weekly semaglutide shot for over a year felt physically better than those who took a dummy shot — their ability to do everyday physical activities improved more, by about twice as much.
A weekly shot called semaglutide helped people with obesity and bad knee arthritis lose way more weight—about 13.7% of their body weight—compared to a fake shot that only led to 3.2% loss, and that weight loss might help their joint pain feel better.