Adults with obesity who took a drug called liraglutide for 6 months, while eating less and exercising, lost more deep belly fat than those who didn’t — and the study says this medicine might help burn that stubborn fat better.

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Evidence from Studies

Supporting (1)

62

Community contributions welcome

62

Weight loss mediates improvement in proinsulin processing during GLP-1 receptor agonist treatment

Randomized Controlled Trial

Human

2025 Jul 18

The study looked at the same weight-loss treatment with liraglutide and metformin, plus diet and exercise, and found people lost more weight and belly fat with liraglutide, which supports the claim.

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Weight loss mediates improvement in proinsulin processing during GLP-1 receptor agonist treatment

Score: 62

DOI: 10.1186/s13098-025-01765-x

Similar Assertions

For adults with obesity, taking liraglutide plus metformin helps you lose more weight than just taking metformin — about 4 extra pounds on average over 6 months.

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If you lose weight on a low-calorie diet, you're more likely to keep it off if you combine liraglutide with aerobic exercise, rather than doing just one of those things — the exercise seems to boost how well the medication works over time.

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If you've lost weight on a low-calorie diet, keeping it off might be easier if you combine aerobic exercise with the drug liraglutide — this combo seems to help burn more fat while preserving muscle better than doing just one or the other over a year.

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