People with very overweight and severe fatty liver also have much worse insulin resistance — meaning their bodies don’t respond well to insulin — compared to those with milder liver fat.

32

Pro

0

Against

Evidence from Studies

Supporting (1)

32

Community contributions welcome

32

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

Cross-Sectional Study

Human

The study found that obese patients with more severe fatty liver also had much higher insulin resistance, just like the claim said — so it supports the claim.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

Score: 32

DOI: 10.1007/s11695-009-0052-z

Similar Assertions

In very overweight people with severe fatty liver, the less SIRT1 gene activity they have in their belly fat, the worse their body’s response to insulin tends to be — meaning their blood sugar control is poorer.

32

0

72%

Eating a low-carb diet for 12 weeks helps people with type 2 diabetes and obesity improve how their liver responds to insulin, making it work better without needing to change their medications.

60

0

70%