Phytic acid triggers the activity of a protein called HDAC3, which plays a role in preserving the lining of the intestines and reducing inflammatory responses.
Mechanism
Synthesis from 2 studies
A natural compound from plants activates a molecular switch in gut cells that silences genes responsible for breaking down the seal between cells. When this seal stays intact, harmful substances can't leak out, preventing inflammation. This process depends on the compound being made inside the gut...
Most probable mechanism
A compound found in plant foods binds to a specific enzyme in gut cells, which triggers another enzyme to remove chemical tags from DNA-related proteins. This turns off genes that make enzymes that break down the glue holding gut cells together. When that glue stays intact, the gut lining stays sealed, preventing harmful substances from leaking into the body and causing inflammation.
Phytic acid is synthesized within intestinal epithelial cells through the enzymatic activity of IPMK, which converts precursor inositol phosphates into phytic acid.
Phytic acid directly binds to the DAD domain of the NCoR1/2 corepressor complex associated with HDAC3, inducing a conformational change that activates HDAC3's deacetylase function.
Activated HDAC3 removes acetyl groups from histone H4 at lysine 16 on the promoter regions of matrix metalloproteinase genes.
Deacetylation of histone H4K16 represses transcription of matrix metalloproteinase genes, reducing production of proteolytic enzymes that degrade tight junction proteins.
Reduced matrix metalloproteinase activity preserves the structural integrity of tight junction proteins such as ZO-1 and occludin, maintaining low paracellular permeability.
Intact tight junctions prevent the translocation of luminal antigens and microbes across the intestinal epithelium, suppressing systemic inflammatory responses.
Evidence from Studies
Supporting (2)
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Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function
Phytic Acid (InsP6) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function
Contradicting (0)
Community contributions welcome
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