How beans help heal your gut
Phytic Acid (InsP6) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Your gut lining needs a special protein called HDAC3 to stay tight and not leak. Beans have a molecule called phytic acid that turns on HDAC3. Without it, your gut gets leaky and inflamed.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Your gut lining needs a special protein called HDAC3 to stay tight and not leak. Beans have a molecule called phytic acid that turns on HDAC3. Without it, your gut gets leaky and inflamed.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
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Claims (10)
HDAC3 is a protein that controls the activity of genes required to keep the lining of the intestine intact and functioning properly.
Phytic acid triggers the activity of a protein called HDAC3, which plays a role in preserving the lining of the intestines and reducing inflammatory responses.
Removing legumes, whole grains, nuts, and seeds from the diet removes phytic acid, which may reduce its role in maintaining the integrity of the intestinal barrier.
Phytic acid triggers a biochemical process that reduces the activity of enzymes called matrix metalloproteinases, which helps maintain the structural integrity of the intestinal lining.
Consuming phytic acid, a compound found in certain plant foods, may help maintain the integrity of the intestinal lining by influencing specific epigenetic mechanisms involving HDAC3.