PLIN2 protein levels in blood cells didn't show any clear relationship with common heart disease risk factors like cholesterol levels, blood sugar, or inflammation markers in people with heart disease.

Scientific Claim

No significant correlations were found between perilipin-2 (PLIN2) protein levels and clinical variables such as body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glycemia, and C-Reactive Protein (CRP) in coronary artery disease patients.

Original Statement

“No correlation was found with other clinical variables such as the body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C); high-density lipoprotein cholesterol (HDL-C); triglycerides (TG); glycemia; and C-Reactive Protein (CRP) (Table S2).”

From study:Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and reports no significant correlations between variables. The claim appropriately states the absence of correlations without implying causation.

Evidence from Studies

Supporting (1)

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Score: 37

DOI: 10.3390/ijms26199550

Similar Assertions

In people with heart disease, older patients tend to have higher levels of PLIN2 protein in their blood cells, and this relationship is stronger in those with stable heart disease than in those having a heart attack.

80%

In people with stable heart disease, older age is more strongly linked to higher PLIN2 protein levels than in people having a heart attack, suggesting age might affect PLIN2 differently in different types of heart disease.

80%

In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.

78%

In people having a heart attack called STEMI, the amount of a protein called PLIN2 in certain blood cells is higher than in people with stable heart disease, which might be related to why their heart attack happened.

75%

In people with stable heart disease, when the proteasome (cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack, suggesting different ways PLIN2 is regulated in these two conditions.

74%