In rats, eating a high-fat, low-carb diet makes their bodies worse at handling sugar—even when calories are the same or higher—but doesn’t change how sensitive they are to insulin. This suggests the sugar problem might not be caused by insulin issues in these animals.

Rats on a low-carb, high-fat diet have trouble handling sugar—even if they're not eating extra calories—and their insulin seems to be working fine, which is weird because those two things usually go together.

When overweight mice eat fewer calories, their blood sugar control gets better — but if their diet is very low in carbs, their blood sugar doesn’t improve as much as if they ate more carbs.

Rats on a very low-carb, high-fat diet for a month ended up with higher blood sugar and more fat in their livers—even if they didn’t eat more calories. This kind of diet might not be great for liver and blood sugar health in animals.

Eating very low-carb, high-fat food for just three days makes blood sugar spike higher after drinking a sugary drink, compared to eating a normal diet.