Scientists are trying to figure out why belly fat affects the liver more than fat under the skin, by comparing how the two types of fat work.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Impact of visceral adipose tissue on liver metabolism

Narrative Review

2008 Sep

The study looks at two types of body fat — one around the organs and one under the skin — and finds that the belly fat releases more harmful substances that affect the liver, just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Impact of visceral adipose tissue on liver metabolism

Score: 1

DOI: 10.1016/j.diabet.2008.04.001

Similar Assertions

Visceral adipose tissue is metabolically active and secretes pro-inflammatory cytokines that impair insulin signaling in liver, muscle, and brain tissues.

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61

83%

Visceral fat is metabolically active tissue that releases cytokines, which impair insulin sensitivity and disrupt metabolic signaling in the liver, muscles, and brain, leading to systemic metabolic dysfunction.

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77%

Visceral adipose tissue releases bioactive molecules directly into the portal venous system, exposing the liver to elevated concentrations of free fatty acids and inflammatory cytokines.

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75%

When too many fat molecules and inflammatory signals from belly fat reach the liver, it becomes less responsive to insulin.

1

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73%

Fat around the organs dumps fat and inflammatory signals straight into the liver through a special blood pipe, where they can mess with liver cells and immune cells.

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72%