When too many fat molecules and inflammatory signals from belly fat reach the liver, it becomes less responsive to insulin.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism.

Narrative Review

2008 Nov

Fat around the belly releases chemicals that go straight to the liver and make it harder for the body to use insulin properly — and this study says exactly that.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism.

Score: 1

DOI: 10.1016/j.diabet.2008.04.002

Similar Assertions

Where fat is stored in the body — especially around the organs — is linked to how the liver processes energy and how sensitive it is to insulin.

1

0

84%

Chronic exposure of the liver to visceral adipose-derived free fatty acids and cytokines induces hepatic steatosis, elevates serum triglycerides, increases blood pressure, and promotes systemic insulin resistance.

32

0

83%

Visceral adipose tissue is metabolically active and secretes pro-inflammatory cytokines that impair insulin signaling in liver, muscle, and brain tissues.

66

61

78%

Too much fat released from belly fat or made by the liver itself clogs liver cells, triggers inflammation, and makes the liver less responsive to insulin.

1

0

76%

Visceral adipose tissue releases bioactive molecules directly into the portal venous system, exposing the liver to elevated concentrations of free fatty acids and inflammatory cytokines.

1

0

75%