Short-term consumption of saccharin and sucralose alters gut microbiota composition and impairs glucose tolerance in a subset of individuals, while acesulfame-K and stevia do not significantly alter glucose tolerance or gut microbiota composition.

Study: 19-OR: Sucralose Consumption Decreases Insulin Sensitivity and Modifies the Gut Microbiota in Healthy Individuals

This study found that drinking or eating things with sucralose for a month changed gut bacteria and made it harder for the body to control blood sugar in healthy people. This matches the claim that sucralose can cause these problems, even if other sweeteners weren’t tested.

Study: Sucralose consumption modifies glucose homeostasis, gut microbiota, Curli protein, and related metabolites in healthy individuals: a randomized placebo-controlled, triple-blind trial.

This study found that drinking a lot of diet soda with sucralose for a month made some people’s bodies worse at handling sugar, and it changed the good bacteria in their guts. Other artificial sweeteners weren’t tested, but for sucralose, it looks like it can cause these problems.

Study: Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance.

This study found that two weeks of eating saccharin or sucralose changed gut bacteria and made some people’s blood sugar harder to control, but acesulfame-K and stevia didn’t do that. So yes, the claim is right.