Certain zero-calorie sweeteners are associated with an increased risk of developing cancer in humans.

Study: Urinary artificial sweeteners and breast cancer risk in women from the Moli-sani Study

The study found that women who had sucralose in their urine were more likely to develop breast cancer before menopause, which suggests that at least one zero-calorie sweetener might increase cancer risk in some people.

Study: Association between Aspartame Consumption and Cancer Risk: Evidence from a Large Prospective Cohort.

The study looked at people who drank diet sodas or used aspartame sweeteners and found they were more likely to get cancer than those who didn’t. This supports the idea that some artificial sweeteners might raise cancer risk.

Study: No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988–2018 Data and 2019 Public-Use Linked Mortality Files

This study looked at thousands of people who use zero-calorie sweeteners like aspartame and saccharin and found no higher risk of cancer compared to those who don’t use them.

Study: MON-324 Systematic Literature Review of Non-caloric Sweeteners: Cancer Risk and Daily Intake Guidelines

The study looked at zero-calorie sweeteners like aspartame and found no strong evidence they cause cancer when people eat them in normal amounts.