Taking 0.15 mg of nonivamide daily in a milk shake for 12 weeks does not change the levels of hormones in the blood that signal fullness, such as GLP-1, PYY, or ghrelin, in adults who are moderately...

We analyzed one assertion about whether 0.15 mg of nonivamide in a milk shake affects satiety hormones in overweight adults, and found no change in blood levels of GLP-1, PYY, or ghrelin after 12 weeks of daily use. This single observation is supported by 60.0 reports, with no studies contradicting it. Nonivamide is a compound related to capsaicin, often found in chili peppers, and is sometimes added to foods for mild heat or potential metabolic effects. Satiety hormones like GLP-1 and PYY help signal fullness after eating, while ghrelin triggers hunger. The evidence we’ve reviewed suggests that at this very low dose — 0.15 mg — taken daily in a milk shake, these hormones do not appear to shift in adults who are moderately overweight over a 12-week period. It’s important to note that this conclusion is based on only one assertion, even though it is supported by 60.0 reports. We don’t know how those reports were gathered, whether they were controlled trials, or if other factors like diet or activity levels were accounted for. There is no evidence here showing that nonivamide increases fullness, reduces appetite, or changes weight — only that these specific hormones stayed the same. What we’ve found so far does not suggest that this small amount of nonivamide in a milk shake has a measurable effect on the body’s signals for hunger or fullness in this group. But with only one assertion analyzed, we can’t say whether higher doses, longer use, or different forms might behave differently. If you’re trying to feel fuller longer, this specific dose and delivery method doesn’t appear to influence the key hormones involved — at least not based on what we’ve reviewed so far.