Can a tiny spice compound help stop weight gain?
A 12‐week intervention with nonivamide, a TRPV1 agonist, prevents a dietary‐induced body fat gain and increases peripheral serotonin in moderately overweight subjects
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave people a tiny amount of a spicy compound (nonivamide) every day to see if it helped them not gain fat, even when eating normally.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 560 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave people a tiny amount of a spicy compound (nonivamide) every day to see if it helped them not gain fat, even when eating normally.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 560 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Hochkogler CM, Lieder B, Rust P, Berry D, Meier SM, Pignitter M, Riva A, Leitinger A, Bruk A, Wagner S, Hans J, Widder S, Ley JP, Krammer GE, Somoza V
Related Content
Claims (6)
Taking 0.15 mg of nonivamide daily may reduce body fat and raise serotonin levels in people who are moderately overweight, but only if their diet is controlled and only for a short time. These effects do not appear in people who are lean, obese, or when taken for longer periods.
Taking 0.15 mg of nonivamide daily for 12 weeks is associated with higher levels of serotonin in the blood after meals in adults with moderate overweight.
In moderately overweight adults, taking 0.15 mg of nonivamide daily for 12 weeks was linked to less increase in body fat compared to those not taking it, with an average difference of –0.61% versus +1.36%. This observation suggests that TRPV1 activation may influence how adipose tissue accumulates during normal eating patterns.
Taking 0.15 mg of nonivamide daily in a milk shake for 12 weeks does not change the levels of hormones in the blood that signal fullness, such as GLP-1, PYY, or ghrelin, in adults who are moderately overweight.
When a person consistently consumes more energy than they expend, the excess energy is stored as body fat.