In moderately overweight adults, taking 0.15 mg of nonivamide daily for 12 weeks was linked to less increase in body fat compared to those not taking it, with an average difference of –0.61% versus...

We analyzed the available evidence on whether taking 0.15 mg of nonivamide daily for 12 weeks affects body fat gain in moderately overweight adults. What we’ve found so far is based on one assertion that suggests a link between this dosage and a smaller increase in body fat compared to not taking it — an average difference of –0.61% versus +1.36% [1]. This single observation does not prove cause and effect, but it does point to a possible association with how the body stores fat during normal eating habits, possibly through TRPV1 activation [1]. We did not find any studies or assertions that contradict this finding, but we also did not find multiple studies to confirm it. The evidence we’ve reviewed leans toward a modest reduction in body fat gain with this supplement, but it is based on only one data point. We cannot say whether this result would hold true across different groups, diets, or longer periods. The term “TRPV1 activation” refers to a biological pathway that may influence fat cells, but we do not know how consistently or strongly this mechanism works in humans at this dose. Because only one assertion was analyzed, and no other research was included, our current understanding is very limited. We cannot say this supplement reliably prevents fat gain, nor can we rule out that future studies might show different results. If you’re considering this supplement, the evidence we’ve reviewed so far is too narrow to make a clear recommendation. More research is needed to understand whether this effect is real, repeatable, and meaningful for most people.