Taking creatine supplements at 10 or 20 grams per day for six weeks does not improve how quickly healthy young adults process information, remember events, or make decisions.

Taking creatine for a week at a high dose doesn't reliably make your brain work better—maybe it helps a little with one type of quick thinking test, but it doesn't help with memory, focus, or other brain skills.

Taking creatine powder at a high dose for a week doesn't make your brain work better in general — except for one tiny improvement in a specific test that measures how quickly you can ignore distractions. Your memory, focus, and decision-making don't improve at all.

Taking creatine every day for six weeks or more doesn't make your memory, focus, or thinking skills any better if you're a healthy adult.

Taking creatine supplements at 10 or 20 grams per day for six weeks does not change the level of oxygen in the prefrontal cortex of healthy young adults when they perform memory or decision-making tasks.

Creatine supplements may not improve brain function in healthy young adults because the dose, length of use, or starting levels of creatine in the body might be too low or too variable, and the study did not directly measure brain creatine levels.