The Claim

Twelve weeks of daily 12 mg cafestol supplementation significantly lowers gamma-glutamyl transferase (GGT) levels by 15% in healthy adults with increased waist circumference, without affecting liver fat content or LDL cholesterol.

Source: Effects of 12-Week Supplementation with Coffee Diterpene Cafestol in Healthy Subjects with Increased Waist Circumference: A Randomized, Placebo-Controlled Trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
73score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Daily supplementation with 12 mg of cafestol for 12 weeks reduces gamma-glutamyl transferase levels by 15% in healthy adults with increased waist circumference, with no change in liver fat content or LDL cholesterol.

See the scientific wording

Twelve weeks of daily 12 mg cafestol supplementation significantly lowers gamma-glutamyl transferase (GGT) levels by 15% in healthy adults with increased waist circumference, indicating reduced liver stress, without affecting liver fat content or LDL cholesterol.

Why this might work

Cafestol enters the body through the gut, travels to fat tissue around the organs, and reduces the amount of fat stored there. This change lowers stress signals sent to the liver, which then produces less of the enzyme GGT. The liver's fat content stays the same, so the effect is not from removing fat from the liver itself, but from improved signaling due to less belly fat.

Supported mechanismbased on 1 study

What the research says

1 study

  1. Study: Effects of 12-Week Supplementation with Coffee Diterpene Cafestol in Healthy Subjects with Increased Waist Circumference: A Randomized, Placebo-Controlled Trial

    This study gave people with extra belly fat 12 mg of cafestol daily for 12 weeks and found their liver stress marker (GGT) dropped by 15%, without changing their liver fat or bad cholesterol — just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.