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Claim
Strong Support
causal
Analysis v3

Taking 200 micrograms of selenium daily for six months increases the percentage of adults with mild Graves’ ophthalmopathy who achieve no active inflammation, from one-third to just over six in ten,...

53
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

Selenium builds special cleanup proteins in the eye area that remove harmful chemicals, which stops immune cells from triggering swelling and redness. This reduces visible signs of inflammation in the eyelids and surrounding tissue.

Most probable mechanism

In Simple Terms

Selenium gets used to make special proteins that clean up harmful chemicals in the eye area, which stops immune cells from causing swelling and redness, leading to less visible inflammation.

Causal chain
1

Oral selenium is absorbed and incorporated into selenoproteins, including glutathione peroxidases and thioredoxin reductases, in liver and orbital tissues

Indirect evidence only
which leads to
2

These selenoproteins reduce hydrogen peroxide and lipid hydroperoxides in orbital connective tissue, lowering oxidative stress

Indirect evidence only
which leads to
3

Reduced oxidative stress inhibits activation of orbital fibroblasts and suppresses NF-kB signaling, decreasing production of interleukin-6 and tumor necrosis factor-alpha

Indirect evidence only
which leads to
4

Lower cytokine levels reduce recruitment and activation of T cells and macrophages in orbital tissues

Indirect evidence only
which leads to
5

Decreased immune cell infiltration and reduced fluid accumulation in orbital connective tissue diminish tissue swelling, particularly in the caruncle and plica

Verified by multiple studies

Evidence from Studies

Supporting (1)

53

Community contributions welcome

53

6662 Effect of Selenium Supplementation on Mild Graves’ Ophthalmopathy at a Tertiary Hospital - A Six-Month Open-Labelled, Assessor-Masked, Randomized-Controlled Trial

Randomized Controlled Trial
Human

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

6662 Effect of Selenium Supplementation on Mild Graves’ Ophthalmopathy at a Tertiary Hospital - A Six-Month Open-Labelled, Assessor-Masked, Randomized-Controlled Trial

Score: 53
DOI: 10.1210/jendso/bvae163.1944

Similar Assertions

In Filipinos with mild Graves’ ophthalmopathy, taking 200 mcg of selenium daily for six months results in a measurable improvement in Clinical Activity Score compared to standard care alone.

53
0
90%

Among adult Filipino patients with mild Graves’ ophthalmopathy lasting less than 18 months, taking 200 micrograms of selenium daily for six months along with standard eye care results in 61.9% of eyes reaching a clinical activity score of 0 at six months, compared to 33.3% in those not taking selenium.

59
0
90%

In patients with mild Graves’ ophthalmopathy, taking 200 mcg of selenium daily for six months is associated with the absence of eyelid redness in all treated individuals, while 9.52% of untreated individuals experienced eyelid redness.

59
0
90%

In areas where people have adequate selenium levels, taking selenium supplements with vitamin B complex for six months may result in a small reduction in eye inflammation symptoms for Graves’ ophthalmopathy, but the evidence is not conclusive because the study was not blinded.

0
62
89%

In patients with mild Graves’ ophthalmopathy, taking 200 mcg of selenium daily for six months is associated with a reduction in swelling of the eye tissues and improved clinical activity scores compared to those not taking selenium.

59
0
89%