Taking 25 mg of prednisolone daily for five days in healthy young men raises the level of active glucocorticoid hormones in the blood by 4.5 times compared to taking a placebo.

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Against

Evidence from Studies

Supporting (1)

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Effects of prednisolone administration on clock gene expression and indices of circadian rhythms in healthy human males.

Randomized Controlled Trial

Human

2026 Mar 17

Contradicting (0)

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No contradicting evidence found

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Source Study

Effects of prednisolone administration on clock gene expression and indices of circadian rhythms in healthy human males.

Score: 62

DOI: 10.1210/clinem/dgaf564

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Taking 25 mg of prednisolone daily for five days raises glucose levels in the body at night by 67% compared to daytime levels in healthy young men, suggesting that the drug interferes with the natural daily rhythm of glucose regulation.

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Taking 25 mg of prednisolone daily for five days raises nighttime systolic blood pressure by about 7 mmHg in healthy young men compared to a placebo, which reduces the normal drop in blood pressure that occurs during sleep.

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