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Strong Support
causal
Analysis v1
History

Taking 25 mg of prednisolone daily for five days lowers sleep efficiency by about 3 percentage points in healthy young adult males, compared to taking a placebo.

62
Pro
0
Against

Evidence from Studies

Supporting (1)

62

Community contributions welcome

62

Effects of prednisolone administration on clock gene expression and indices of circadian rhythms in healthy human males.

Randomized Controlled Trial
Human
2026 Mar 17

Contradicting (0)

0

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No contradicting evidence found

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Source Study

Effects of prednisolone administration on clock gene expression and indices of circadian rhythms in healthy human males.

Score: 62
DOI: 10.1210/clinem/dgaf564

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Taking 25 mg of prednisolone daily for five days raises glucose levels in the body at night by 67% compared to daytime levels in healthy young men, suggesting that the drug interferes with the natural daily rhythm of glucose regulation.

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Taking 25 mg of prednisolone daily for five days raises nighttime systolic blood pressure by about 7 mmHg in healthy young men compared to a placebo, which reduces the normal drop in blood pressure that occurs during sleep.

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Taking 25 mg of prednisolone daily for five days reduces the natural daily fluctuations in the activity of key clock genes in muscle and fat tissue, suggesting the drug directly interferes with the body's internal timing system in these tissues.

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Taking 25 mg of prednisolone daily for five days in healthy young men raises the level of active glucocorticoid hormones in the blood by 4.5 times compared to taking a placebo.

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