The Claim

Administration of 10 mg of melatonin nightly for 24 weeks significantly improves New York Heart Association (NYHA) functional class, enhances daily physical capacity, and reduces symptom burden in patients with stable heart failure with reduced ejection fraction compared to placebo.

Source: Melatonin supplementation improves N‐terminal pro‐B‐type natriuretic peptide levels and quality of life in patients with heart failure with reduced ejection fraction: Results from MeHR trial, a randomized clinical trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
74score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Taking 10 mg of melatonin every night for six months may help people with a specific type of heart condition feel more energetic and experience fewer symptoms. This supplement could make it easier for them to handle daily physical activities compared to taking a placebo.

See the scientific wording

Administration of 10 mg melatonin nightly for 24 weeks significantly improves New York Heart Association (NYHA) functional class in patients with stable heart failure with reduced ejection fraction, with an odds ratio of 12.9 favoring functional improvement compared to placebo, indicating enhanced daily physical capacity and reduced symptom burden.

What the research says

1 study

  1. Study: Melatonin supplementation improves N‐terminal pro‐B‐type natriuretic peptide levels and quality of life in patients with heart failure with reduced ejection fraction: Results from MeHR trial, a randomized clinical trial

    The study used logistic regression adjusted for baseline NYHA class, age, and sex to analyze functional class changes. The highly significant odds ratio indicates that melatonin supplementation causally increases the likelihood of patients improving their functional classification, translating to better daily physical capacity and reduced symptom severity.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.