The Study
Melatonin supplementation improves N‐terminal pro‐B‐type natriuretic peptide levels and quality of life in patients with heart failure with reduced ejection fraction: Results from MeHR trial, a randomized clinical trial
This study is a randomized controlled trial, which is like a fair test where people are randomly split into two groups to see if a treatment works. It can prove that melatonin actually caused the improvements in heart failure symptoms and quality of life for the people in this study. However, because it only lasted 24 weeks and had a small number of participants, we can't be sure if it works for everyone or prevents serious events like death.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Researchers tested if taking a 10 mg melatonin pill every night for six months helps people with a specific type of heart failure.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 574 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes, the improvements in daily symptoms and heart stress markers suggest melatonin could be a helpful, low-risk add-on therapy for managing heart failure symptoms and daily functioning.
- 2Patients taking melatonin had lower stress hormone levels in their blood, felt better in their daily lives, and could handle more physical activity.
- 3It did not change the heart's pumping strength or reduce inflammation.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Clinical Cardiology
Year
2022
Authors
S. Hoseini, K. Heshmat-Ghahdarijani, Saeid Khosrawi, Mohammad Garakyaraghi, Davood Shafie, M. Mansourian, H. Roohafza, E. Azizi, Masoumeh Sadeghi
Related Content
Claims (7)
Taking 10 mg of melatonin every day for six months helps heart failure patients feel better and live more comfortably, according to a study comparing it to a placebo.
Taking 10 mg of melatonin every night for six months may help people with a specific type of heart condition feel more energetic and experience fewer symptoms. This supplement could make it easier for them to handle daily physical activities compared to taking a placebo.
Taking 10 mg of melatonin every night for six months can help people with a specific type of heart condition feel better and have fewer heart failure flare-ups. This improvement comes from better daily well-being and fewer hospital visits, rather than from preventing death.
Taking 10 mg of melatonin every day for six months does not appear to lower inflammation or help with sleep, anxiety, and depression in people with a specific type of heart failure. This suggests that melatonin is not very helpful for these particular symptoms in this patient group.
Taking a 10-milligram melatonin pill every night for six months can significantly lower a specific heart stress marker in people with a common type of heart failure. This drop in the marker suggests the supplement might help calm the body's stress hormones that strain the heart.
Taking 10 mg of melatonin every night for six months does not improve heart pumping ability or change heart size in people with a specific type of chronic heart failure.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.