Daily oral supplementation with 60 mg of a hyaluronic acid matrix containing hyaluronic acid, chondroitin sulfate, dermatan sulfate, and collagen for 12 weeks increases stratum corneum hydration by approximately 10-11 AU and increases skin brightness by 1.3 AU in healthy women aged 35–65, as measured on the periocular and cheek areas.

When taken by mouth, the ingredients in the supplement enter the bloodstream and reach the deeper layer of the skin, where they trigger cells to make more water-trapping molecules and structural proteins. This increases water content in the skin's foundation, which pulls moisture upward into the outer layer, making it smoother and more hydrated. At the same time, the supplement reduces redness and heat in the skin by calming blood vessels and inflammation, allowing light to reflect more evenly off the surface, making the skin look brighter.