The Study
Oral Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study
This study gave some women a pill and others a fake pill to see if the real one made their skin look better. It found that the real pill helped a little with hydration and glow, but only in the women who took it for 12 weeks. We can’t say it will work for everyone, or that it fixes aging — just that it helped these specific women in this short time.
Analysis score
Maximum 45 for a randomized controlled trial.
Where the score came from
A pill with special skin-friendly ingredients (hyaluronic acid and others) was given to women to see if it helps their skin look and feel better.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 545 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — these changes are noticeable in real life: smoother, brighter, less red and flaky skin that people can see and feel.
- 2After 3 months, women who took the pill had 10–11 units more skin moisture, 1.3 units brighter skin, 71 units smoother skin, less flakiness, less redness, and 69% said they were very satisfied — compared to only 42% in the placebo group.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Dermatology and Therapy
Year
2025
Authors
Trinidad Montero‐Vílchez, Patricia Gálvez-Martín, R. Sanabria-de la Torre, C. Cuenca-Barrales, A. Molina‐Leyva, D. Martínez-Puig, J. Velasco-Álvarez, S. Arias-Santiago
Related Content
Claims (5)
Taking 60 mg of a hyaluronic acid supplement daily for 12 weeks reduces skin roughness on the cheeks and increases skin smoothness around the eyes in healthy women aged 35 to 65.
Taking a daily oral supplement containing hyaluronic acid, chondroitin sulfate, dermatan sulfate, and collagen for 12 weeks increases skin hydration by 10-11 AU and skin brightness by 1.3 AU in women aged 35 to 65.
Taking 60 milligrams of a hyaluronic acid supplement daily for 12 weeks reduces skin flakiness around the eyes by 0.8 SEsc units in healthy women aged 35 to 65.
Taking 60 mg of a hyaluronic acid supplement daily for 12 weeks results in 69.2% of healthy women aged 35–65 reporting satisfaction or very high satisfaction with their skin appearance, compared to 41.7% of women taking a placebo.
Taking 60 mg of a hyaluronic acid supplement daily for 12 weeks lowers skin redness by 23.3 AU around the eyes in healthy women aged 35 to 65.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.