The Claim

A daily multinutrient supplement containing 82 µg of vitamin B12 for 4 months significantly increases serum vitamin B12, holotranscobalamin, and the combined vitamin B12 status indicator (cB12) in healthy vegan adults aged 19–57 in Germany.

Source: Assessment of vitamin A, vitamin B2, vitamin B12, vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
82score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Taking a daily supplement with 82 micrograms of vitamin B12 for four months raises levels of vitamin B12, holotranscobalamin, and a combined biomarker of vitamin B12 status in healthy vegan adults aged 19 to 57 in Germany.

See the scientific wording

A daily multinutrient supplement containing 82 µg of vitamin B12 for 4 months significantly increases serum vitamin B12, holotranscobalamin, and the combined vitamin B12 status indicator (cB12) in healthy vegan adults aged 19–57 in Germany, demonstrating a causal improvement in vitamin B12 biomarkers that are critical for neurological and hematological function.

Why this might work

When a person takes a vitamin B12 pill, the vitamin is absorbed in the lower intestine and binds to a protein that carries it into the bloodstream. This carrier protein delivers vitamin B12 directly to cells throughout the body, where it is used to support essential chemical reactions. As more vitamin B12 becomes available to cells, blood tests show higher levels of the active form and improved markers that reflect how well the body is using it.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Assessment of vitamin A, vitamin B2, vitamin B12, vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial

    This study gave vegans a daily pill with 82 micrograms of B12 for four months and found their blood levels of B12 went up significantly compared to those who took a fake pill. So yes, the supplement works.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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