Taking a supplement called DIM every day for a month doesn’t seem to change a certain hormone balance in premenopausal Mexican women that’s linked to lower breast cancer risk — but there might be a slight improvement a month after stopping.

54

Pro

0

Against

Evidence from Studies

Supporting (1)

54

Community contributions welcome

54

Effectiveness of 3,3′-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women

Randomized Controlled Trial

Human

2023

The study looked at the same supplement and group of women described in the claim and found no significant increase in a cancer-related hormone ratio, but saw a small upward trend after stopping the supplement.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effectiveness of 3,3′-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women

Score: 54

DOI: 10.1080/01635581.2022.2123535

Similar Assertions

If postmenopausal women using estrogen patches also take a supplement called DIM, it might change how their body processes estrogen—lowering some types linked to higher risk and raising others that may be safer.

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Premenopausal Mexican women tend to have lower levels of a certain estrogen-related marker in their urine compared to other groups, and this might mean they're at higher risk for breast cancer because lower levels of this marker are linked to more cancer cases.

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Taking a daily supplement with certain plant compounds might help your body process estrogen in a healthier way, which could lower the risk of some hormone-related cancers in women, whether or not they’ve gone through menopause.

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Taking DIM supplements might help boost a certain healthy estrogen process in postmenopausal women who use estrogen patches — one study found their urine had 24% more of a specific marker linked to this process.

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