correlational
Analysis v1
Strong Opposition

Taking betaine supplements (4–6 grams a day) for a few months might slightly raise your 'bad' cholesterol by about 5 points, which could cancel out some of the heart benefits you get from lowering another blood chemical called homocysteine.

0
Pro
65
Against

Evidence from Studies

Supporting (0)

0

Community contributions welcome

No supporting evidence found

Contradicting (1)

65

Community contributions welcome

This study only looked at whether betaine lowers homocysteine (a blood chemical), and it does. But it didn’t check if betaine raises cholesterol, which is the other part of the claim — so we can’t say if the claim about cholesterol is true or false.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.