correlational
Analysis v1
Strong Opposition
Taking betaine supplements (4–6 grams a day) for a few months might slightly raise your 'bad' cholesterol by about 5 points, which could cancel out some of the heart benefits you get from lowering another blood chemical called homocysteine.
0
65
Evidence from Studies
Supporting (0)
0
Community contributions welcome
No supporting evidence found
Contradicting (1)
65
Community contributions welcome
65
Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis.
Systematic Review With Meta-Analysis
Human
2013 MarThis study only looked at whether betaine lowers homocysteine (a blood chemical), and it does. But it didn’t check if betaine raises cholesterol, which is the other part of the claim — so we can’t say if the claim about cholesterol is true or false.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.