Taking betaine supplements may raise levels of betaine and some related compounds in your blood, slightly increase your 'bad' cholesterol, and lower a harmful substance called homocysteine — but it’s not clear if this is good or bad for your health.

Taking betaine supplements (4–6 grams a day) for a few months might slightly raise your 'bad' cholesterol by about 5 points, which could cancel out some of the heart benefits you get from lowering another blood chemical called homocysteine.

Taking betaine supplements doesn't seem to make a noticeable difference in your blood fats, sugar, inflammation, liver health, or blood pressure — at least not in most adults.

Taking betaine supplements for a few months might raise your 'bad' cholesterol a little bit—about 5 points—which could cancel out the heart benefits you get from lowering another blood chemical called homocysteine.

Taking betaine supplements doesn’t change your ‘good’ cholesterol or fat levels in your blood, but it does lower your ‘bad’ cholesterol and overall cholesterol — so it’s picky about which fats it affects.

Taking betaine, a natural compound found in foods like beets and spinach, can slightly lower a substance in your blood called homocysteine—which, when too high, might be bad for your heart. This suggests betaine helps your body process certain nutrients better.