Taking betaine supplements doesn't seem to make a noticeable difference in your blood fats, sugar, inflammation, liver health, or blood pressure — at least not in most adults.

Taking betaine supplements may raise levels of betaine and some related compounds in your blood, slightly increase your 'bad' cholesterol, and lower a harmful substance called homocysteine — but it’s not clear if this is good or bad for your health.

Taking betaine supplements doesn’t change your ‘good’ cholesterol or fat levels in your blood, but it does lower your ‘bad’ cholesterol and overall cholesterol — so it’s picky about which fats it affects.

Taking betaine supplements doesn’t change your ‘good’ cholesterol or fat levels in the blood, but it might lower your ‘bad’ cholesterol without messing up anything else in your lipid system.

Taking betaine supplements (4–6 grams a day) for a few months might slightly raise your 'bad' cholesterol by about 5 points, which could cancel out some of the heart benefits you get from lowering another blood chemical called homocysteine.

Taking betaine supplements doesn't change the level of choline in your blood, which means your body doesn't use betaine to make or use choline right away.