Taking betaine supplements doesn't change the level of choline in your blood, which means your body doesn't use betaine to make or use choline right away.

Taking betaine supplements doesn't change the levels of amino acids in the blood of healthy, active guys, which means it doesn't really mess with how their bodies use or balance proteins.

Taking betaine supplements doesn’t change your ‘good’ cholesterol or fat levels in the blood, but it might lower your ‘bad’ cholesterol without messing up anything else in your lipid system.

Taking betaine supplements doesn't seem to make a noticeable difference in your blood fats, sugar, inflammation, liver health, or blood pressure — at least not in most adults.

Taking betaine supplements may raise levels of betaine and some related compounds in your blood, slightly increase your 'bad' cholesterol, and lower a harmful substance called homocysteine — but it’s not clear if this is good or bad for your health.

Taking betaine supplements can boost the amount of betaine in your blood by more than three times, which means your body easily absorbs and uses it.