Taking CLA supplements for a few weeks may cause more damage to fats in your body, similar to how trans fats do, based on a chemical marker in urine.

Eating a lot of artificial trans fats for a few weeks makes your body produce more of a chemical that shows your fats are being damaged by stress, like rust forming on metal.

Taking CLA supplements for three weeks doesn’t seem to change most common signs of inflammation in the blood, even though it might increase oxidative stress.