Taking CLA supplements for three weeks doesn’t seem to change most common signs of inflammation in the blood, even though it might increase oxidative stress.

Taking CLA supplements for a few weeks may cause more damage to fats in your body, similar to how trans fats do, based on a chemical marker in urine.

Even when people ate a lot of a specific trans fat found in dairy (CLA), their blood proteins stayed pretty much the same, so this type of fat probably doesn’t change how the body uses proteins in the blood.