Taking creatine every day while your leg is immobilized might help keep your muscles' ability to handle sugar working better, so they don’t weaken as much.

Taking creatine while rebuilding leg strength after being inactive might help your muscles improve faster by boosting a key protein that helps with energy use.

Taking creatine might help your muscles keep using sugar properly when you're not moving much, and help them rebuild faster when you start moving again.

If you're a healthy young adult getting back into strength training after resting your leg for two weeks, taking creatine might give you more energy in your muscles and boost creatine levels after three weeks — but by ten weeks, that advantage goes away.

In young, healthy guys, creatine helps refill muscle energy after intense exercise, but it doesn’t work by making muscles more sensitive to insulin — that part hasn’t changed, according to tests and gene activity.

Taking creatine supplements the way some athletes do—starting with a big dose, then switching to a smaller one—might temporarily boost the sugar stored in your muscles, but that boost fades once you switch to the smaller daily dose.