The Claim
Oral administration of a combination of L-citrulline and L-arginine at half-dose each rapidly increases plasma L-arginine concentration and elevates plasma nitric oxide metabolites (NOx) and cyclic GMP in rats and rabbits, indicating enhanced nitric oxide bioavailability within hours of ingestion.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Oral intake of equal halves of L-citrulline and L-arginine increases plasma L-arginine levels and raises nitric oxide metabolites and cyclic GMP in rats and rabbits within hours.
See the scientific wording
Oral administration of a combination of L-citrulline and L-arginine at half-dose each rapidly increases plasma L-arginine concentration and elevates plasma nitric oxide metabolites (NOx) and cyclic GMP in rats and rabbits, indicating enhanced nitric oxide bioavailability within hours of ingestion.
When L-citrulline and L-arginine are taken together by mouth, the body converts L-citrulline into more L-arginine in the kidneys, which raises the amount of L-arginine in the blood. This extra L-arginine feeds into blood vessel cells, where it is turned into nitric oxide. Nitric oxide then signals nearby muscle cells in the blood vessel walls to relax by increasing a chemical called cyclic GMP, which causes the vessels to widen and blood flow to increase.
What the research says
1 studyTaking L-citrulline and L-arginine together by mouth quickly boosts a key chemical in the blood that helps blood vessels relax, and this study in rats and rabbits proves it works fast.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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