Taking NAC along with regular stroke treatment lowers a measure of harmful oxidative stress in the blood of stroke patients.
Scientific Claim
N-acetylcysteine administration significantly reduces total oxidant status (TOS) in ischemic stroke patients when added to standard treatment, with a mean decrease from 113.28 ± 12.57 to 79.70 ± 8.25 (p=0.02) in the intervention group compared to no significant change in the control group.
Original Statement
“TOSIntervention/before = 113.28 ± 12.57 versus TOSIntervention/after = 79.70 ± 8.25 (P = 0.02)”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
probability
Can suggest probability/likelihood
Assessment Explanation
This is an RCT with appropriate statistical analysis showing significant reduction. The verb 'reduces' is appropriate but should be qualified with 'likely' or 'significantly' given the single-center design and moderate sample size.
More Accurate Statement
“N-acetylcysteine administration likely significantly reduces total oxidant status (TOS) in ischemic stroke patients when added to standard treatment, with a mean decrease from 113.28 ± 12.57 to 79.70 ± 8.25 (p=0.02) in the intervention group compared to no significant change in the control group.”
Evidence from Studies
Supporting (1)
Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke