When comparing stroke patients who received NAC to those who didn't, only one blood marker related to oxidative stress showed a significant difference between the groups.

Scientific Claim

N-acetylcysteine administration did not significantly improve most oxidative stress biomarkers in the overall ischemic stroke patient group when compared to the control group, with only total oxidant status (TOS) showing a significant difference (p=0.02).

Original Statement

“When comparing control and intervention groups, we found no significant difference between the results of studied parameters except for TOS. The p values corresponding to each test are as following: TAC: P = 0.46, TOS: P = 0.02, MDA: P = 0.44, catalase: P = 0.75, paraoxonase: P = 0.97, and neopterin: P = 0.09.”

From study:Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

probability

Can suggest probability/likelihood

Assessment Explanation

The RCT design supports the conclusion that only TOS showed significant difference between groups. The verb 'did not significantly improve' is appropriate for this finding.

Evidence from Studies

Supporting (1)

Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke

Randomized Controlled Trial

Human

Contradicting (0)

No contradicting evidence found

Source Study

Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke

Score: 58

DOI: 10.1186/s43088-023-00380-x

Similar Assertions

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For most stroke patients, NAC treatment didn't significantly change most blood markers related to oxidative stress compared to standard treatment alone.

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