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Back to Study: Randomized Crossover Clinical Trial of Nicotinamid...
mechanistic
Analysis v1
Strong Support

Taking certain supplements like nicotinamide riboside or CoQ10 for six weeks might help reduce harmful stress in the body for people with moderate to severe kidney disease.

72
Pro
0
Against

Evidence from Studies

Supporting (1)

72

Community contributions welcome

72

Randomized Crossover Clinical Trial of Nicotinamide Riboside and Coenzyme Q10 on Metabolic Health and Mitochondrial Bioenergetics in CKD

Randomized Controlled Trial
Human

The study gave people with kidney disease either NR or CoQ10 for six weeks and found that both lowered a key marker of body stress, just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Randomized Crossover Clinical Trial of Nicotinamide Riboside and Coenzyme Q10 on Metabolic Health and Mitochondrial Bioenergetics in CKD

Score: 72
DOI: 10.1101/2024.08.23.24312501

Similar Assertions

Taking certain supplements like nicotinamide riboside or coenzyme Q10 might help lower signs of body stress in people with serious kidney disease.

72
0
88%

Taking a supplement called nicotinamide riboside every day for six weeks might help reduce harmful stress in the body for adults with moderate to severe kidney disease.

72
0
87%

Taking 1200 mg of CoQ10 every day for six weeks might help reduce harmful stress in the body for adults with moderate to severe kidney disease.

72
0
86%

In people with moderate to severe kidney disease, taking either nicotinamide riboside or coenzyme Q10 for six weeks seems to change how certain genes work in the blood — one affects energy and fat processing, while the other influences immunity and stress, suggesting they work in different ways.

72
0
84%

In people with moderate to severe kidney disease, taking 1000 mg of nicotinamide riboside daily for six weeks may boost energy in immune cells, but the same doesn’t happen with a high dose of CoQ10.

72
0
80%