Can vitamins help kidney disease by fixing cell energy and reducing damage?
Randomized Crossover Clinical Trial of Nicotinamide Riboside and Coenzyme Q10 on Metabolic Health and Mitochondrial Bioenergetics in CKD
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NR increased IL-2, an immune-activating signal, while CoQ10 reduced IL-13, an allergy-linked cytokine.
Most supplements aim to reduce all immune activity in chronic disease, but NR boosted a pro-inflammatory signal—potentially helpful or risky depending on context.
Practical Takeaways
People with moderate-to-severe CKD might consider NR or CoQ10 to reduce oxidative stress, under medical supervision.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NR increased IL-2, an immune-activating signal, while CoQ10 reduced IL-13, an allergy-linked cytokine.
Most supplements aim to reduce all immune activity in chronic disease, but NR boosted a pro-inflammatory signal—potentially helpful or risky depending on context.
Practical Takeaways
People with moderate-to-severe CKD might consider NR or CoQ10 to reduce oxidative stress, under medical supervision.
Publication
Journal
medRxiv
Year
2024
Authors
A. Ahmadi, A. P. Valencia, G. Begue, J. Norman, Sili Fan, Blythe P. Durbin-Johnson, Bradley N Jenner, Matthew D. Campbell, Gustavo Reyes, Pankaj Kapahi, Jonathan Himmelfarb, I. D. de Boer, D. Marcinek, Bryan R. Kestenbaum, Jorge L. Gamboa, B. Roshanravan
Related Content
Claims (6)
Taking a supplement called nicotinamide riboside every day for six weeks might boost a protein in the blood that affects the immune system in people with moderate to severe kidney disease — but we don’t know yet if that change actually helps or matters for their health.
In people with moderate to severe kidney disease, taking either nicotinamide riboside or coenzyme Q10 for six weeks seems to change how certain genes work in the blood — one affects energy and fat processing, while the other influences immunity and stress, suggesting they work in different ways.
Taking certain supplements like nicotinamide riboside or CoQ10 for six weeks might help reduce harmful stress in the body for people with moderate to severe kidney disease.
In people with moderate to severe kidney disease, taking 1000 mg of nicotinamide riboside daily for six weeks may boost energy in immune cells, but the same doesn’t happen with a high dose of CoQ10.
Taking 1200 mg of CoQ10 every day for six weeks might help lower two key markers of inflammation in people with moderate to severe kidney disease, even though one of the markers didn’t stay significant when checked more strictly.