Taking NR or NMN supplements by mouth seems to boost a key molecule called NAD+ in your blood, which scientists think might be good for aging, but we don’t know yet if it actually makes a real difference to health.

What we've found so far is that taking NR or NMN supplements by mouth appears to increase levels of NAD+ in the blood of humans [1]. Our analysis of the available research shows this effect has been observed across multiple studies, with 28.0 supporting assertions and none refuting it [1]. NAD+ is a molecule involved in energy production and cell health, and levels tend to drop as people age. The evidence we've reviewed leans toward the conclusion that these supplements can raise NAD+ levels when taken orally [1]. This has been measured directly in blood samples, which gives us confidence in the finding. However, what we don’t know yet is whether this increase leads to meaningful changes in health, aging, or disease risk. The studies we’ve analyzed so far focus on NAD+ levels as a biological marker, not on long-term outcomes like improved energy, longer life, or reduced age-related illness [1]. Our current analysis shows a consistent pattern that NR and NMN boost NAD+ in humans, but we’re still missing the link between higher NAD+ and actual health benefits. There’s also no evidence in our review that addresses potential risks or side effects over time. We’re continuing to track new research as it becomes available. Right now, the data is clear on the biochemical effect—NAD+ goes up—but unclear on what that means for your health. Practical takeaway: If you're considering NR or NMN, know that they likely raise NAD+ levels, but it’s still unknown whether that translates into real-world health improvements.